If someone told you there was an activity that increased brain-derived neurotrophic factor by 200–300%, promoted the growth of new neurons in your memory center, counteracted the effects of chronic stress on your brain, and required no gym membership—you’d probably want to know what it was.
It’s sex. The research is more robust than you’d expect.
The BDNF Surge
Brain-derived neurotrophic factor (BDNF) is the protein that supports existing neurons and encourages the growth of new ones. It’s essentially fertilizer for your brain. And sexual activity triggers a significant, measurable spike in it.
A study examining BDNF expression in the hippocampus after sexual activity found that BDNF mRNA levels increased 2.03-fold at 6 hours post-activity and 2.94-fold at 24 hours—nearly tripling baseline levels.[1]
New Neurons From Sex
The University of Maryland found that regular sexual activity allowed for neurogenesis—the creation of new neurons—and improved cognitive function. A 2010 study established that sexual experience causes cell growth in the hippocampus, the brain region instrumental to long-term memory.[2]
This is significant because adult neurogenesis was once thought impossible. We now know the hippocampus continues generating new neurons throughout life—and sexual activity is one of the factors that promotes this process.
The Stress-Erasing Effect
Perhaps the most remarkable finding is that sexual activity counteracts the brain-damaging effects of chronic stress. Chronic stress suppresses hippocampal neurogenesis and impairs recognition memory. But in stressed subjects, regular sexual activity restored both new neuron survival and memory function to levels comparable to unstressed controls.[1]
The mechanism appears to work through BDNF and its receptor TrkB, combined with the CREB transcription factor. Sexual activity increases expression of all three, creating a neurochemical environment that actively protects the brain from stress damage.
The Neurochemical Cocktail
During orgasm, your brain releases a simultaneous cascade of neurochemicals:
Dopamine: The reward and motivation neurotransmitter. Surges during arousal and peaks at orgasm. Also plays a role in memory consolidation and working memory.[3]
Oxytocin: Supports social bonding and stress reduction. Emerging research suggests it may support neuroplasticity—the brain’s ability to reorganize and form new connections.[3]
Serotonin: Mood regulation and emotional well-being. Post-orgasm serotonin contributes to the sense of calm and satisfaction that follows sexual activity.
Endorphins: Natural pain relief and euphoria. The post-sex “glow” is a measurable neurochemical state, not just a metaphor.
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References
[1] Kim, H. et al. (2013). Sexual activity counteracts the suppressive effects of chronic stress on adult hippocampal neurogenesis and recognition memory. Brain Research, 1538, 26–40.
[2] Leuner, B. et al. (2010). Sexual experience promotes adult neurogenesis in the hippocampus. PLoS ONE, 5(7).
[3] Vella Bio (2025). Sex and Mental Health: How Orgasms Boost Brain Health.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Content reviewed by Dr. [Medical Reviewer], MD. Always consult a qualified healthcare provider before starting any treatment. Individual results vary. ED can be a sign of underlying health conditions that require professional evaluation.